Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Oryctolagus cuniculus |
- |
Mus musculus |
- |
Sus scrofa |
Crystallization (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
H176N | the mutant activity decreases 25% regarding Vmax | Homo sapiens |
L149P | the mutant is inactivated by 90% | Homo sapiens |
N140S | the mutant possesses only traces of wild type activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-methyl-tetrahydrofolate | - |
Homo sapiens | |
5-methyl-tetrahydrofolate | - |
Mus musculus | |
5-methyl-tetrahydrofolate | - |
Oryctolagus cuniculus | |
5-methyl-tetrahydrofolate | - |
Rattus norvegicus | |
5-methyl-tetrahydrofolate | - |
Sus scrofa | |
5-Methyltetrahydrofolate pentaglutamate | noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine | Homo sapiens | |
5-Methyltetrahydrofolate pentaglutamate | noncompetitive inhibitor regarding substrates S-adenosyl-L-methionine and glycine | Mus musculus | |
5-Methyltetrahydrofolate pentaglutamate | noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine | Oryctolagus cuniculus | |
5-Methyltetrahydrofolate pentaglutamate | noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine | Rattus norvegicus | |
5-Methyltetrahydrofolate pentaglutamate | noncompetitive inhibitor with respect to substrates S-adenosyl-L-methionine and glycine | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
cytosol | - |
Oryctolagus cuniculus | 5829 | - |
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Sus scrofa | 5829 | - |
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Rattus norvegicus | 5634 | - |
nucleus | - |
Oryctolagus cuniculus | 5634 | - |
nucleus | - |
Mus musculus | 5634 | - |
nucleus | - |
Sus scrofa | 5634 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
32500 | - |
4 * 32500 | Homo sapiens |
32500 | - |
4 * 32500 | Rattus norvegicus |
32500 | - |
4 * 32500 | Oryctolagus cuniculus |
32500 | - |
4 * 32500 | Mus musculus |
32500 | - |
4 * 32500 | Sus scrofa |
130000 | - |
- |
Homo sapiens |
130000 | - |
- |
Rattus norvegicus |
130000 | - |
- |
Oryctolagus cuniculus |
130000 | - |
- |
Mus musculus |
130000 | - |
- |
Sus scrofa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | Q9QXF8 | - |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | Q29555 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 | Homo sapiens |
phosphoprotein | GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 | Rattus norvegicus |
phosphoprotein | GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 | Oryctolagus cuniculus |
phosphoprotein | GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 | Sus scrofa |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Oryctolagus cuniculus |
- |
Mus musculus |
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocellular carcinoma cell | - |
Homo sapiens | - |
hepatocellular carcinoma cell | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Mus musculus | - |
kidney | - |
Sus scrofa | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Oryctolagus cuniculus | - |
liver | - |
Mus musculus | - |
liver | - |
Sus scrofa | - |
additional information | no GNMT activity is detected in fetal liver, Novikoff hepatoma cells, Morris hepatoma cells, and Ehrlich ascites cells | Homo sapiens | - |
additional information | no GNMT activity is detected in fetal liver, Novikoff hepatoma cells, Morris hepatoma cells, and Ehrlich ascites cells | Mus musculus | - |
pancreas | - |
Homo sapiens | - |
pancreas | - |
Rattus norvegicus | - |
pancreas | - |
Mus musculus | - |
pancreas | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | GNMT is phosphorylated by cAMP-dependent protein kinase at Ser9, Ser71, Ser139, Ser182, and Ser241 | Mus musculus | ? | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Homo sapiens | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Oryctolagus cuniculus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Mus musculus | S-adenosyl-L-homocysteine + N-methylglycine | - |
? | |
S-adenosyl-L-methionine + glycine | - |
Sus scrofa | S-adenosyl-L-homocysteine + N-methylglycine | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | 4 * 32500 | Homo sapiens |
homotetramer | 4 * 32500 | Rattus norvegicus |
homotetramer | 4 * 32500 | Oryctolagus cuniculus |
homotetramer | 4 * 32500 | Mus musculus |
homotetramer | 4 * 32500 | Sus scrofa |
Synonyms | Comment | Organism |
---|---|---|
GNMT | - |
Homo sapiens |
GNMT | - |
Rattus norvegicus |
GNMT | - |
Oryctolagus cuniculus |
GNMT | - |
Mus musculus |
GNMT | - |
Sus scrofa |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Rattus norvegicus | - |
- |
6.4 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.001 | - |
at pH 9.0 | Rattus norvegicus | 5-Methyltetrahydrofolate pentaglutamate | |
0.002 | - |
at pH 7.5 | Rattus norvegicus | 5-Methyltetrahydrofolate pentaglutamate |